Article
Nonenzymatic release of N7-methylguanine channels repair of abasic sites into an AP endonuclease-independent pathway in Arabidopsis.
Proceedings of the National Academy of Sciences of the United States of America - 30 Jan 2018
Barbado Casimiro, Córdoba-Cañero Dolores, Ariza Rafael R, Roldán-Arjona Teresa
Abstract excerpt
Abasic (apurinic/apyrimidinic, AP) sites in DNA arise from spontaneous base loss or by enzymatic removal during base excision repair. It is commonly accepted that both classes of AP site have analogous biochemical properties and are equivalent substrates for AP endonucleases and AP lyases, although the relative roles of these two types of enzymes are not well understood. We provide here genetic and biochemical...
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