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Article

Disentangling human tolerance and resistance against HIV.

PLoS biology - 1 Sept 2014

Regoes Roland R, McLaren Paul J, Battegay Manuel, Bernasconi Enos, Calmy Alexandra, Günthard Huldrych F, Hoffmann Matthias, Rauch Andri, Telenti Amalio, Fellay Jacques

Abstract excerpt

In ecology, "disease tolerance" is defined as an evolutionary strategy of hosts against pathogens, characterized by reduced or absent pathogenesis despite high pathogen load. To our knowledge, tolerance has to date not been quantified and disentangled from host resistance to disease in any clinically relevant human infection. Using data from the Swiss HIV Cohort Study, we investigated if there is variation in...

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Share to CD4 Lymphocyte Count
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Host-Pathogen Interactions

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Share to Receptors, CCR5

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Source

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Identifiers

PMID: 25226169
DOI: 10.1371/journal.pbio.1001951
PMCID: PMC4165755

Genes

CCR5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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