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Article

Sequence analysis of the catalytic subunit of PKA in somatotroph adenomas.

European journal of endocrinology - 1 Dec 2014

Larkin Sarah J, Ferraù Francesco, Karavitaki Niki, Hernández-Ramírez Laura C, Ansorge Olaf, Grossman Ashley B, Korbonits Márta

Abstract excerpt

OBJECTIVE: The pathogenetic mechanisms of sporadic somatotroph adenomas are not well understood, but derangements of the cAMP pathway have been implicated. Recent studies have identified L206R mutations in the alpha catalytic subunit of protein kinase A (PRKACA) in cortisol-producing adrenocortic...

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Source

Identifiers

PMID: 25225481
DOI: 10.1530/EJE-14-0545

Genes

PRKACA
PRKACB
GNAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-25225481-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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Sequence analysis of the catalytic subunit of PKA in somatotroph adenomas.PMID 25225481Read ↗

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PRKAR1A, one of the Carney complex genes, and its locus (17q22-24) are rarely altered in pituitary tumours outside the Carney complex: Figure 1Semantic proximity Read ↗

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