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Article

Evidence that PKA activity is constitutively activated in human GH-secreting adenoma cells in a patient with Carney complex harbouring a PRKAR1A mutation.

Clinical endocrinology - 1 May 2009

Takano Koji, Yasufuku-Takano Junko, Morita Koji, Mori Shigetoshi, Takei Mao, Osamura Robert Yoshiyuki, Teramoto Akira, Fujita Toshiro

Abstract excerpt

CONTEXT: The GHRH-protein kinase A (PKA) signalling pathway is essential for cell proliferation and GH synthesis/secretion in somatotrophs. An inactivating mutation of PRKAR1A is one of the causes of somatotrophinoma in Carney complex (CNC). The basal PKA activity of somatotroph adenoma cells from CNC has not been evaluated because of a limited amount of available tissue. OBJECTIVE: This study examined how the...

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Source

Identifiers

PMID: 19178533
DOI: 10.1111/j.1365-2265.2008.03457.x

Genes

GHRH

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Evidence that PKA activity is constitutively activated in human GH-secreting adenoma cells in a patient with Carney complex harbouring a PRKAR1A mutation.PMID 19178533Read ↗

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