PRKAR1A, one of the Carney complex genes, and its locus (17q22-24) are rarely altered in pituitary tumours outside the Carney complex: Figure 1

Abstract excerpt

The tumour suppressor gene encoding the cAMP dependent protein kinase A (PKA) type I-α regulatory subunit (RIα), PRKAR1A , has been mapped to chromosome 17q22-24 and is often mutated in the Carney complex (CNC),1,2 a multiple neoplasia and lentiginosis syndrome inherited in an autosomal dominant manner.3,4 The complex was first described as an association of lentigines, primary pigmented nodular adrenocortical...

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