Article
Landscape of somatic mutations in sporadic GH-secreting pituitary adenomas.
European journal of endocrinology - 1 Mar 2016
Ronchi Cristina L, Peverelli Erika, Herterich Sabine, Weigand Isabel, Mantovani Giovanna, Schwarzmayr Thomas, Sbiera Silviu, Allolio Bruno, Honegger Jürgen, Appenzeller Silke, Lania Andrea G, Reincke Martin, Calebiro Davide, Spada Anna, Buchfelder Michael, Flitsch Joerg, Strom Tim M, Fassnacht Martin
Abstract excerpt
CONTEXT: Alterations in the cAMP signaling pathway are common in hormonally active endocrine tumors. Somatic mutations at GNAS are causative in 30-40% of GH-secreting adenomas. Recently, mutations affecting the USP8 and PRKACA gene have been reported in ACTH-secreting pituitary adenomas and cortisol-secreting adrenocortical adenomas respectively. However, the pathogenesis of many GH-secreting adenomas remains...
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