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Article

Mutational analysis of PRKAR1A and Gs(alpha) in sporadic adrenocortical tumors.

Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association - 1 May 2005

Libé R, Mantovani G, Bondioni S, Lania A G, Pedroni C, Beck-Peccoz P, Spada A

Abstract excerpt

Little is known about the pathogenesis of adrenocortical tumors. The cAMP-dependent pathway is physiologically activated by ACTH in adrenocortical cells and different components of this cascade may be altered in some functioning adrenocortical tumors. Recently, mutations of the gene encoding the PKA type 1 A regulatory subunit (R1 A), PRKAR1A, associated with loss of heterozygosity (LOH) at PRKAR1A locus, have...

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Share to Adrenal Cortex Neoplasms
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cyclic AMP-Dependent Protein Kinase RIalpha Subunit

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Share to DNA Mutational Analysis

Share to GTP-Binding Protein alpha Subunits, Gs

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Source

Identifiers

PMID: 15926108
DOI: 10.1055/s-2005-837651

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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