Article
Phenotypes of flavin-containing monooxygenase activity determined by ranitidine N-oxidation are positively correlated with genotypes of linked FM03 gene mutations in a Korean population.
Pharmacogenetics - 1 Feb 2000
Kang J H, Chung W G, Lee K H, Park C S, Kang J S, Shin I C, Roh H K, Dong M S, Baek H M, Cha Y N
Abstract excerpt
A non-invasive urine analysis method to determine the in-vivo flavin-containing mono-oxygenase (FMO) activity catalysing N-oxidation of ranitidine (RA) was developed and used to phenotype a Korean population. FMO activity was assessed by the molar concentration ratio of RA and RANO in the bulked 8 h urine. This method was used to determine the FMO phenotypes of 210 Korean volunteers (173 men and 37 women, 110...
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