A meta-analysis of cancer risk associated with the TP53 intron 3 duplication polymorphism (rs17878362): geographic and tumor-specific effects.

doi:10.1038/cddis.2013.24

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Article

A meta-analysis of cancer risk associated with the TP53 intron 3 duplication polymorphism (rs17878362): geographic and tumor-specific effects.

Cell death & disease - 14 Feb 2013

Sagne C, Marcel V, Amadou A, Hainaut P, Olivier M, Hall J

Abstract excerpt

We have performed a meta-analysis of cancer risk associated with the rs17878362 polymorphism of the TP53 suppressor gene (PIN3, (polymorphism in intron 3), 16 bp sequence insertion/duplication in intron 3), using a compilation of a total of 25 published studies with 10 786 cases and 11 760 controls. Homozygote carriers of the duplicated allele (A2A2) had a significantly increased cancer risk compared with A1A1...

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PMID: 23412385
DOI: 10.1038/cddis.2013.24
PMCID: PMC3734845

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