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Article

Down-regulation of NKG2D and NKp80 ligands by Kaposi's sarcoma-associated herpesvirus K5 protects against NK cell cytotoxicity.

Proceedings of the National Academy of Sciences of the United States of America - 5 Feb 2008

Thomas Mair, Boname Jessica M, Field Sarah, Nejentsev Sergey, Salio Mariolina, Cerundolo Vincenzo, Wills Mark, Lehner Paul J

Abstract excerpt

Natural killer (NK) cells are important early mediators of host immunity to viral infections. The NK activatory receptors NKG2D and NKp80, both C-type lectin-like homodimeric receptors, stimulate NK cell cytotoxicity toward target cells. Like other herpesviruses, Kaposi's sarcoma-associated herpesvirus (KSHV) down-regulates MHC class I molecules to avoid detection by cytotoxic T lymphocytes but renders cells...

Read the complete abstract on PubMed

Topics

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Share to Cytotoxicity, Immunologic
Share to Herpesvirus 8, Human

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Immediate-Early Proteins

Share to Lectins, C-Type

Share to Lysosomes

Share to NK Cell Lectin-Like Receptor Subfamily K

Share to Receptors, Natural Killer Cell

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Source

Open in PubMed Open full text

Identifiers

PMID: 18230726
DOI: 10.1073/pnas.0707883105
PMCID: PMC2234200

Genes

MICA
MICB

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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