CEBPA copy number variations in normal karyotype acute myeloid leukemia: Possible role of breakpoint-associated microhomology and chromatin status in CEBPA mutagenesis.

doi:10.1016/j.bcmd.2015.07.002

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

CEBPA copy number variations in normal karyotype acute myeloid leukemia: Possible role of breakpoint-associated microhomology and chromatin status in CEBPA mutagenesis.

Blood cells, molecules & diseases - 1 Dec 2015

Libura Marta, Pawełczyk Marta, Florek Izabella, Matiakowska Karolina, Jaźwiec Bożena, Borg Katarzyna, Solarska Iwona, Zawada Magdalena, Czekalska Sylwia, Libura Jolanta, Salamanczuk Zoriana, Jakóbczyk Małgorzata, Mucha Barbara, Duszeńko Ewa, Soszyńska Krystyna, Karabin Karolina, Piątkowska-Jakubas Beata, Całbecka Małgorzata, Gajkowska-Kulig Justyna, Gadomska Grażyna, Kiełbiński Marek, Ejduk Anna, Kata Dariusz, Grosicki Sebastian, Kyrcz-Krzemień Sławomira, Warzocha Krzysztof, Kuliczkowski Kazimierz, Skotnicki Aleksander, Jęrzejczak Wiesław Wiktor, Haus Olga

Abstract excerpt

Copy number variations (CNV) in CEBPA locus represent heterogeneous group of mutations accompanying acute myeloid leukemia (AML). The aim of this study was to characterize different CEBPA mutation categories in regard to biological data like age, cytology, CD7, and molecular markers, and identify possible factors affecting their etiology. We report here the incidence of 12.6% of CEBPA mutants in the population of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to CCAAT-Enhancer-Binding Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Chromatin

Share to Chromosome Breakpoints

Share to DNA Copy Number Variations

Share to Gene Expression Regulation, Leukemic

Share to Karyotype

Share to Leukemia, Myeloid, Acute

Share to Nucleotide Motifs

Source

Open in PubMed

Identifiers

PMID: 26460249
DOI: 10.1016/j.bcmd.2015.07.002

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

CEBPA copy number variations in normal karyotype acute myeloid leukemia: Possible role of breakpoint-associated microhomology and chromatin status in CEBPA mutagenesis.PMID 26460249Read ↗

A case of acute myeloid leukemia with unusual germline CEBPA mutation: lessons learned about mutation detection, location, and penetrance.Semantic proximity Read ↗

Acute Myeloid Leukemia With Biallelic CEBPA Gene Mutations and Normal Karyotype Represents a Distinct Genetic Entity Associated With a Favorable Clinical OutcomeSemantic proximity Read ↗

Mutational spectrum of acute myeloid leukemia patients with double CEBPA mutations based on next-generation sequencing and its prognostic significanceSemantic proximity Read ↗

Characterization of CEBPA mutations in acute myeloid leukemia: most patients with CEBPA mutations have biallelic mutations and show a distinct immunophenotype of the leukemic cells.Semantic proximity Read ↗

Molecular evaluation of CEBPA gene mutation in normal karyotype acute myeloid leukemia: a comparison of two methods and report of novel CEBPA mutations from Indian acute myeloid leukemia patients.Semantic proximity Read ↗

CCAAT/enhancer binding protein-alpha polymorphisms occur more frequently than mutations in acute myeloid leukemia and exist across all cytogenetic risk groups and leukemia subtypes.Semantic proximity Read ↗

A novel mutation in CEBPA gene in a patient with acute myeloid leukemia.Semantic proximity Read ↗

Acute myeloid leukemia with biallelic CEBPA gene mutations and normal karyotype represents a distinct genetic entity associated with a favorable clinical outcome.Semantic proximity Read ↗

Acute Myeloid Leukemia With CEBPA Mutations: Current Progress and Future DirectionsSemantic proximity Read ↗

Haploinsufficiency of ETV6 and CDKN1B in patients with acute myeloid leukemia and complex karyotype.Semantic proximity Read ↗

Mutations in the bZip region of the CEBPA gene: A novel prognostic factor in patients with acute myeloid leukemia.Semantic proximity Read ↗

Genetic heterogeneity of cytogenetically normal AML with mutations of CEBPASemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.