Article
The dynamics and pH-dependence of Ag43 adhesins' self-association probed by atomic force spectroscopy.
Nanoscale - 7 Nov 2014
Jacquot Adrien, Sakamoto Chizuko, Razafitianamarahavo Angelina, Caillet Céline, Merlin Jenny, Fahs Ahmad, Ghigo Jean-Marc, Duval Jérôme F L, Beloin Christophe, Francius Grégory
Abstract excerpt
Self-associating auto-transporter (SAAT) adhesins are two-domain cell surface proteins involved in bacteria auto-aggregation and biofilm formation. Antigen 43 (Ag43) is a SAAT adhesin commonly found in Escherichia coli whose variant Ag43a has been shown to promote persistence of uropathogenic E. coli within the bladder. The recent resolution of the tri-dimensional structure of the 499 amino-acids' β-domain in...
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