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A viral vector expressing hypoxia-inducible factor 1 alpha inhibits hippocampal neuronal apoptosis

1 Jan 2014

Abstract excerpt

Hypoxia-inducible factor 1 (HIF-1) attenuates amyloid-beta protein neurotoxicity and decreases apoptosis induced by oxidative stress or hypoxia in cortical neurons. In this study, we constructed a recombinant adeno-associated virus (rAAV) vector expressing the human HIF-1α gene (rAAV-HIF-1α), and tested the assumption that rAAV-HIF-1α represses hippocampal neuronal apoptosis induced by amyloid-beta protein. Our...

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PMID: 25206774
DOI: 10.4103/1673-5374.135317

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