Article
Tumor necrosis factor induces Bcl-2 and Bcl-x expression through NFkappaB activation in primary hippocampal neurons.
The Journal of biological chemistry - 26 Mar 1999
Tamatani M, Che Y H, Matsuzaki H, Ogawa S, Okado H, Miyake S, Mizuno T, Tohyama M
Abstract excerpt
Emerging data indicate that tumor necrosis factor (TNF) exerts a neuroprotective effect in response to brain injury. Here we examined the mechanism of TNF in preventing neuronal death in primary hippocampal neurons. TNF protected neurons against hypoxia- or nitric oxide-induced injury, with an increase in the anti-apoptotic proteins Bcl-2 and Bcl-x as determined by Western blot and reverse...
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