Article
Functional exploration of SNP mutations in HIF2αb gene correlated with hypoxia tolerance in blunt snout bream (Megalobrama amblycephala).
Fish physiology and biochemistry - 1 Apr 2023
Zhao Shan-Shan, Su Xiao-Lei, Yang Hui-Qi, Zheng Guo-Dong, Zou Shu-Ming
Abstract excerpt
Blunt snout bream (Megalobrama amblycephala) is sensitive to hypoxia environment. Hypoxia-inducible factor (HIF) is the most critical factor in the HIF pathway, which strictly regulates the hypoxia stress process of fish. In this study, we found six hifα genes in blunt snout bream that demonstrated different expressions under hypoxia conditions. In HEK293T cells, all six hifαs were detected to activate the HRE...
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