Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

RNAi-mediated knockdown of E2F2 inhibits tumorigenicity of human glioblastoma cells

22 Jul 2014

Abstract excerpt

In a previous genome‑wide expression profiling study, we identified E2F2 as a hyperexpressed gene in stem‑like cells of distinct glioblastoma multiforme (GBM) specimens. Since the encoded E2F2 transcription factor has been implicated in both tumor suppression and tumor development, we conducted a functional study to investigate the pertinence of E2F2 to human gliomagenesis. E2F2 expression was knocked down by...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Epigenetics and DNA Methylation
Share to Glioma Diagnosis and Treatment
Share to MicroRNA in disease regulation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 25202354
DOI: 10.3892/ol.2014.2369

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

RNAi-mediated knockdown of E2F2 inhibits tumorigenicity of human glioblastoma cellsPMID 25202354Read ↗

E2F7−EZH2 axis regulates PTEN/AKT/mTOR signalling and glioblastoma progressionSemantic proximity Read ↗

Expression and prognostic role of E2F transcription factors in high‐grade gliomaSemantic proximity Read ↗

The role of E2F2 in cancer progression and its value as a therapeutic targetSemantic proximity Read ↗

Pathway-based approach reveals differential sensitivity of glioblastoma to E2F1 inhibitionSemantic proximity Read ↗

E2F transcription factors associated with up-regulated genes in glioblastomaSemantic proximity Read ↗

Sox2-dependent maintenance of mouse oligodendroglioma involves the Sox2-mediated downregulation of Cdkn2b, Ebf1, Zfp423 and Hey2Semantic proximity Read ↗

miR‐125b regulates the proliferation of glioblastoma stem cells by targeting E2F2Semantic proximity Read ↗

Sox2 Promotes Malignancy in Glioblastoma by Regulating Plasticity and Astrocytic DifferentiationSemantic proximity Read ↗

LncRNA SBF2-AS1 Promotes Malignant Phenotypes and Radioresistance of Glioblastoma Cells by Impairing miR-338-3p-targeted MAP4K3 InhibitionSemantic proximity Read ↗

Molecular targeting of TRF2 suppresses the growth and tumorigenesis of glioblastoma stem cellsSemantic proximity Read ↗

Silencing of Insulin-like Growth Factor-binding Protein-2 in Human Glioblastoma Cells Reduces Both Invasiveness and Expression of Progression-associated Gene CD24Semantic proximity Read ↗

SOX2 silencing in glioblastoma tumor-initiating cells causes stop of proliferation and loss of tumorigenicity.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.