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Article

Towards accurate characterization of clonal heterogeneity based on structural variation.

BMC bioinformatics - 8 Sept 2014

Fan Xian, Zhou Wanding, Chong Zechen, Nakhleh Luay, Chen Ken

Abstract excerpt

BACKGROUND: Recent advances in deep digital sequencing have unveiled an unprecedented degree of clonal heterogeneity within a single tumor DNA sample. Resolving such heterogeneity depends on accurate estimation of fractions of alleles that harbor somatic mutations. Unlike substitutions or small indels, structural variants such as deletions, duplications, inversions and translocations involve segments of DNAs and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 25201439
DOI: 10.1186/1471-2105-15-299
PMCID: PMC4165998

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