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Article

Direct regulation of topoisomerase activity by a nucleoid-associated protein.

Nucleic acids research - 1 Jan 2014

Ghosh Soumitra, Mallick Bratati, Nagaraja Valakunja

Abstract excerpt

The topological homeostasis of bacterial chromosomes is maintained by the balance between compaction and the topological organization of genomes. Two classes of proteins play major roles in chromosome organization: the nucleoid-associated proteins (NAPs) and topoisomerases. The NAPs bind DNA to compact the chromosome, whereas topoisomerases catalytically remove or introduce supercoils into the genome. We...

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PMID: 25200077
DOI: 10.1093/nar/gku804
PMCID: PMC4176182

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