Article
Cell competition promotes phenotypically silent cardiomyocyte replacement in the mammalian heart.
Cell reports - 25 Sept 2014
Villa Del Campo Cristina, Clavería Cristina, Sierra Rocío, Torres Miguel
Abstract excerpt
Heterogeneous anabolic capacity in cell populations can trigger a phenomenon known as cell competition, through which less active cells are eliminated. Cell competition has been induced experimentally in stem/precursor cell populations in insects and mammals and takes place endogenously in early mouse embryonic cells. Here, we show that cell competition can be efficiently induced in mouse cardiomyocytes by mosaic...
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