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Article

Existing cardiomyocytes generate cardiomyocytes at a low rate after birth in mice.

Proceedings of the National Academy of Sciences of the United States of America - 17 Jun 2014

Ali Shah R, Hippenmeyer Simon, Saadat Lily V, Luo Liqun, Weissman Irving L, Ardehali Reza

Abstract excerpt

The mammalian heart has long been considered a postmitotic organ, implying that the total number of cardiomyocytes is set at birth. Analysis of cell division in the mammalian heart is complicated by cardiomyocyte binucleation shortly after birth, which makes it challenging to interpret traditional assays of cell turnover [Laflamme MA, Murray CE (2011) Nature 473(7347):326-335; Bergmann O, et al. (2009) Science...

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Identifiers

PMID: 24876275
DOI: 10.1073/pnas.1408233111
PMCID: PMC4066522

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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