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Article

Herpes simplex virus serotype and entry receptor availability alter CNS disease in a mouse model of neonatal HSV.

Pediatric research - 1 Dec 2014

Kopp Sarah J, Ranaivo Hantamalala R, Wilcox Douglas R, Karaba Andrew H, Wainwright Mark S, Muller William J

Abstract excerpt

BACKGROUND: Outcomes of neonates with herpes simplex virus (HSV) encephalitis are worse after infection with HSV-2 when compared with HSV-1. The proteins herpes virus entry mediator (HVEM) and nectin-1 mediate HSV entry into susceptible cells. Prior studies have shown receptor-dependent differences in pathogenesis that depend on route of inoculation and host developmental age. METHODS: We investigated...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 25198371
DOI: 10.1038/pr.2014.135
PMCID: PMC4233006

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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