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Article

Herpesvirus entry mediator is a serotype specific determinant of pathogenesis in ocular herpes

26 Nov 2012

Abstract excerpt

Infection with herpes simplex virus type 1 (HSV-1) and HSV-2 is initiated by viral glycoprotein D (gD) binding to a receptor on the host cell. Two receptors, herpesvirus entry mediator (HVEM) and nectin-1, mediate entry in murine models of HSV-1 and HSV-2. HVEM is dispensable for HSV-2 infection of the vagina and brain, but is required for WT pathogenesis of HSV-1 infection of the cornea. By challenging WT and...

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PMID: 23184983
DOI: 10.1073/pnas.1216967109

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Research trail→

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Herpesvirus entry mediator is a serotype specific determinant of pathogenesis in ocular herpesPMID 23184983Read ↗

Partial or complete blocking of gD binding to HVEM affects primary and latent HSV-1 infection as well as eye disease in HSV-1 infected mice.Semantic proximity Read ↗

Herpesvirus Entry Mediator and Ocular Herpesvirus Infection: More than Meets the EyeSemantic proximity Read ↗

Functional interaction between herpes simplex virus type 2 gD and HVEM transiently dampens local chemokine production after murine mucosal infection.Semantic proximity Read ↗

Herpes simplex virus serotype and entry receptor availability alter CNS disease in a mouse model of neonatal HSV.Semantic proximity Read ↗

Nectin-1-specific entry of herpes simplex virus 1 is sufficient for infection of the cornea and viral spread to the trigeminal ganglia.Semantic proximity Read ↗

Characterization of Sex Differences in Ocular HSV-1 Infection and Herpes Stromal Keratitis Pathogenesis of Wild Type and Herpesvirus Entry Mediator Knockout MiceSemantic proximity Read ↗

Complete disruption of gD binding to HVEM alters virus replication and host receptor homeostasis.Semantic proximity Read ↗

Comparative usage of herpesvirus entry mediator A and nectin-1 by laboratory strains and clinical isolates of herpes simplex virus.Semantic proximity Read ↗

The herpes simplex virus JMP mutant enters receptor-negative J cells through a novel pathway independent of the known receptors nectin1, HveA, and nectin2.Semantic proximity Read ↗

Mutations in herpes simplex virus glycoprotein D that prevent cell entry via nectins and alter cell tropism.Semantic proximity Read ↗

Structure-based mutagenesis of herpes simplex virus glycoprotein D defines three critical regions at the gD-HveA/HVEM binding interface.Semantic proximity Read ↗

A replication competent HSV-1(McKrae) with a mutation in the amino-terminus of glycoprotein K (gK) is unable to infect mouse trigeminal ganglia after cornea infection.Semantic proximity Read ↗

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