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Viral infection of human neurons triggers strain-specific differences in host neuronal and viral transcriptomes

22 Mar 2021

Abstract excerpt

Infection with herpes simplex virus 1 (HSV-1) occurs in over half the global population, causing recurrent orofacial and/or genital lesions. Individual strains of HSV-1 demonstrate differences in neurovirulence in vivo, suggesting that viral genetic differences may impact phenotype. Here differentiated SH-SY5Y human neuronal cells were infected with one of three HSV-1 strains known to differ in neurovirulence in...

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PMID: 33750985
DOI: 10.1371/journal.ppat.1009441

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