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Article

Phosphatidylinositol 3-kinase (PI3K) pathway activation in bladder cancer.

Cancer metastasis reviews - 1 Dec 2009

Knowles Margaret A, Platt Fiona M, Ross Rebecca L, Hurst Carolyn D

Abstract excerpt

The phosphatidylinositol 3-kinase (PI3K) pathway is a critical signal transduction pathway that regulates multiple cellular functions. Aberrant activation of this pathway has been identified in a wide range of cancers. Several pathway components including AKT, PI3K and mTOR represent potential therapeutic targets and many small molecule inhibitors are in development or early clinical trials. The complex...

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Identifiers

PMID: 20013032
DOI: 10.1007/s10555-009-9198-3
PMCID: PMC2797439

Genes

AKT1
PTEN
TSC1

Provenance

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