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Article

Competitive mode and site of interaction of ticagrelor at the human platelet P2Y12 -receptor.

Journal of thrombosis and haemostasis : JTH - 1 Nov 2014

Hoffmann K, Lutz D A, Straßburger J, Baqi Y, Müller C E, von Kügelgen I

Abstract excerpt

BACKGROUND: The G-protein-coupled P2Y12 -receptor plays a crucial role in platelet aggregation. Recently, ticagrelor was licensed as the first perorally active and reversible P2Y12 -receptor antagonist. OBJECTIVE: The present study investigated the site and the antagonistic mode of action of ticagrelor at wild-type or mutant human P2Y12 -receptors. METHODS: Recombinant wild-type or mutant human P2Y12 -receptors...

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Identifiers

PMID: 25186974
DOI: 10.1111/jth.12719

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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