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Article

Influence of P2Y12 polymorphisms on platelet activity but not ex-vivo antiplatelet effect of ticagrelor in healthy Chinese male subjects.

Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis - 1 Dec 2015

Li Mu-Peng, Tang Jie, Wen Zhi-Peng, Zhang Yan-Jiao, Zhang Wei, Zhou Hong-Hao, Zhang Zan-Ling, Chen Xiao-Ping

Abstract excerpt

Activation of platelet implicated a series of signal conduction including outside-in and inside-out related receptor-mediated signaling pathways. Ticagrelor is the first reversible P2Y12 receptor antagonist that exhibits rapid antiplatelet effect. Given that platelet aggregation varies among individuals, genetic polymorphisms in P2Y12 and subsequent signal molecular such as the G-protein beta 3 subunit (GNB3) are...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 26083990
DOI: 10.1097/MBC.0000000000000308

Genes

GNB3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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