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Article

Tracing the roots of cancer evolution.

Cancer discovery - 1 Sept 2014

Jiang Yanwen, Elemento Olivier

Abstract excerpt

SUMMARY: By comparing the genomes of progenitor cells and mature cells of lymphoid and myeloid lineages in patients with chronic lymphocytic leukemia (CLL), Damm and colleagues confirmed that CLL originates from preleukemic CD34(+) progenitor cells and identified early CLL mutations that are associated with these progenitor cells. Moreover, they discovered that deregulation of B-cell receptor signaling may be one...

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Identifiers

PMID: 25185189
DOI: 10.1158/2159-8290.CD-14-0743
PMCID: PMC4155509

Genes

EGR2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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