Article
Redox-responsive repressor Rex modulates alcohol production and oxidative stress tolerance in Clostridium acetobutylicum.
Journal of bacteriology - 1 Nov 2014
Zhang Lei, Nie Xiaoqun, Ravcheev Dmitry A, Rodionov Dmitry A, Sheng Jia, Gu Yang, Yang Sheng, Jiang Weihong, Yang Chen
Abstract excerpt
Rex, a transcriptional repressor that modulates its DNA-binding activity in response to NADH/NAD(+) ratio, has recently been found to play a role in the solventogenic shift of Clostridium acetobutylicum. Here, we combined a comparative genomic reconstruction of Rex regulons in 11 diverse clostridial species with detailed experimental characterization of Rex-mediated regulation in C. acetobutylicum. The...
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