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Article

NAD+ pool depletion as a signal for the Rex regulon involved in Streptococcus agalactiae virulence

9 Aug 2021

Abstract excerpt

In many Gram-positive bacteria, the redox-sensing transcriptional repressor Rex controls central carbon and energy metabolism by sensing the intra cellular balance between the reduced and oxidized forms of nicotinamide adenine dinucleotide; the NADH/NAD+ ratio. Here, we report high-resolution crystal structures and characterization of a Rex ortholog (Gbs1167) in the opportunistic pathogen, Streptococcus...

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PMID: 34370789
DOI: 10.1371/journal.ppat.1009791

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