Elimination of carbon catabolite repression in Clostridium acetobutylicum--a journey toward simultaneous use of xylose and glucose.

Abstract excerpt

The industrial Gram-positive anaerobe Clostridium acetobutylicum is a valued acetone, butanol, and ethanol (ABE) solvent producer that is able to utilize a vast array of carbon sources in fermentation. When glucose is present in the growth medium, however, C. acetobutylicum, like many Gram-positive organisms, exhibits biphasic growth characteristics in which glucose is used preferentially over secondary carbon...

Topics

• Catabolite Repression
• Clostridium acetobutylicum
• Gene Expression Regulation, Bacterial
• Glucose
• Metabolic Networks and Pathways
• Mutation
• Response Elements
• Xylose