Article
Preferential association of a functional variant in complement receptor 2 with antibodies to double-stranded DNA.
Annals of the rheumatic diseases - 1 Jan 2016
Zhao Jian, Giles Brendan M, Taylor Rhonda L, Yette Gabriel A, Lough Kara M, Ng Han Leng, Abraham Lawrence J, Wu Hui, Kelly Jennifer A, Glenn Stuart B, Adler Adam J, Williams Adrienne H, Comeau Mary E, Ziegler Julie T, Marion Miranda, Alarcón-Riquelme Marta E, Alarcón Graciela S, Anaya Juan-Manuel, Bae Sang-Cheol, Kim Dam, Lee Hye-Soon, Criswell Lindsey A, Freedman Barry I, Gilkeson Gary S, Guthridge Joel M, Jacob Chaim O, James Judith A, Kamen Diane L, Merrill Joan T, Sivils Kathy Moser, Niewold Timothy B, Petri Michelle A, Ramsey-Goldman Rosalind, Reveille John D, Scofield R Hal, Stevens Anne M, Vilá Luis M, Vyse Timothy J, Kaufman Kenneth M, Harley John B, Langefeld Carl D, Gaffney Patrick M, Brown Elizabeth E, Edberg Jeffrey C, Kimberly Robert P, Ulgiati Daniela, Tsao Betty P, Boackle Susan A
Abstract excerpt
OBJECTIVES: Systemic lupus erythematosus (SLE; OMIM 152700) is characterised by the production of antibodies to nuclear antigens. We previously identified variants in complement receptor 2 (CR2/CD21) that were associated with decreased risk of SLE. This study aimed to identify the causal variant for this association. METHODS: Genotyped and imputed genetic variants spanning CR2 were assessed for association with...
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