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Article

An allelic variant of Crry in the murine Sle1c lupus susceptibility interval is not impaired in its ability to regulate complement activation.

Journal of immunology (Baltimore, Md. : 1950) - 15 Aug 2010

Tchepeleva Svetlana N, Thurman Joshua M, Ruff Katherine, Perkins Stephen J, Morel Laurence, Boackle Susan A

Abstract excerpt

The Sle1c subinterval on distal murine chromosome 1 confers loss of tolerance to chromatin. Cr2, which encodes complement receptors 1 and 2 (CR1/CR2; CD35/CD21), is a strong candidate gene for lupus susceptibility within this interval based on structural and functional alterations in its protein...

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PMID: 20660348
DOI: 10.4049/jimmunol.1000783
PMCID: PMC3073420

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20660348-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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