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Article

Usefulness of immunohistochemistry for the detection of the BRAF V600E mutation in ovarian serous borderline tumors.

Oncology reports - 1 Nov 2014

Hayashi Yuko, Sasaki Hidefumi, Takeshita Sho, Nishikawa Ryutaro, Nishikawa Hiroshi, Arakawa Atsushi, Yamashita Yoriko, Takahashi Satoru, Sugiura-Ogasawara Mayumi

Abstract excerpt

Serous borderline tumors and low-grade serous adenocarcinomas typically exhibit a low mitotic index and are largely resistant to chemotherapy. They are characterized by specific mutations, including mutations of KRAS and BRAF, which target specific cell signaling pathways. Mutational analyses may provide further insight into the development sequence of low-grade serous carcinomas. There are 3 methods to detect...

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Share to Cystadenocarcinoma, Serous
Share to DNA Mutational Analysis

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Immunohistochemistry

Share to Ovarian Neoplasms

Share to Polymerase Chain Reaction

Share to Proto-Oncogene Proteins B-raf

Share to Reproducibility of Results

Share to Sensitivity and Specificity

Source

Identifiers

PMID: 25174456
DOI: 10.3892/or.2014.3442

Genes

BRAF
CAST
KRAS

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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