Article
α-Catenin levels determine direction of YAP/TAZ response to autophagy perturbation.
Nature communications - 17 Mar 2021
Pavel Mariana, Park So Jung, Frake Rebecca A, Son Sung Min, Manni Marco M, Bento Carla F, Renna Maurizio, Ricketts Thomas, Menzies Fiona M, Tanasa Radu, Rubinsztein David C
Abstract excerpt
The factors regulating cellular identity are critical for understanding the transition from health to disease and responses to therapies. Recent literature suggests that autophagy compromise may cause opposite effects in different contexts by either activating or inhibiting YAP/TAZ co-transcriptional regulators of the Hippo pathway via unrelated mechanisms. Here, we confirm that autophagy perturbation in...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.