Article
Investigation of association between donors' and recipients' NADPH oxidase p22(phox) C242T polymorphism and acute rejection, delayed graft function and blood pressure in renal allograft recipients.
Transplant immunology - 1 Jan 2015
Mandegary Ali, Rahmanian-Koshkaki Sara, Mohammadifar Mohammad-Amir, Pourgholi Leila, Mehdipour Mohammad, Etminan Abbas, Ebadzadeh Mohammad-Reza, Fazeli Faramarz, Azmandian Jalal
Abstract excerpt
BACKGROUND: Production of reactive oxygen species (ROS) and thereby induction of oxidative stress seem to be one of the major mediators of inflammatory adverse outcomes after renal transplantation. p22(phox) is a polymorphic subunit of NAD(P)H-oxidase that is critical for activation and stabilization of the enzyme. This enzyme is involved in the production of superoxide that triggers inflammatory injuries to the...
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