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The FgfrL1 receptor is required for development of slow muscle fibers

27 Aug 2014

Abstract excerpt

FgfrL1, which interacts with Fgf ligands and heparin, is a member of the fibroblast growth factor receptor (Fgfr) family. FgfrL1-deficient mice show two significant alterations when compared to wildtype mice: They die at birth due to a malformed diaphragm and they lack metanephric kidneys. Utilizing gene arrays, qPCR and in situ hybridization we show here that the diaphragm of FgfrL1 knockout animals lacks any...

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PMID: 25172430
DOI: 10.1016/j.ydbio.2014.08.016

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