Article
Beyond GWAS in COPD: probing the landscape between gene-set associations, genome-wide associations and protein-protein interaction networks.
Human heredity - 1 Jan 2014
McDonald Merry-Lynn Noelle, Mattheisen Manuel, Cho Michael H, Liu Yang-Yu, Harshfield Benjamin, Hersh Craig P, Bakke Per, Gulsvik Amund, Lange Christoph, Beaty Terri H, Silverman Edwin K
Abstract excerpt
OBJECTIVES: To use a systems biology approach to integrate genotype and protein-protein interaction (PPI) data to identify disease network modules associated with chronic obstructive pulmonary disease (COPD) and to perform traditional pathway analysis. METHODS: We utilized a standard gene-set association approach (FORGE) using gene-based association analysis and gene-set definitions from the molecular signatures...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.