Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Comparison of the heritability of schizophrenia and endophenotypes in the COGS-1 family study.

Schizophrenia bulletin - 1 Nov 2014

Light Gregory, Greenwood Tiffany A, Swerdlow Neal R, Calkins Monica E, Freedman Robert, Green Michael F, Gur Raquel E, Gur Ruben C, Lazzeroni Laura C, Nuechterlein Keith H, Olincy Ann, Radant Allen D, Seidman Larry J, Siever Larry J, Silverman Jeremy M, Sprock Joyce, Stone William S, Sugar Catherine A, Tsuang Debby W, Tsuang Ming T, Turetsky Bruce I, Braff David L

Abstract excerpt

BACKGROUND: Twin and multiplex family studies have established significant heritability for schizophrenia (SZ), often summarized as 81%. The Consortium on the Genetics of Schizophrenia (COGS-1) family study was designed to deconstruct the genetic architecture of SZ using neurocognitive and neurophysiological endophenotypes, for which heritability estimates ranged from 18% to 50% (mean = 30%). This study assessed...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Endophenotypes
Share to Family

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genetic Predisposition to Disease

Share to Nuclear Family

Share to Psychotic Disorders

Share to Schizophrenia

Source

Open in PubMed Open full text

Identifiers

PMID: 24903414
DOI: 10.1093/schbul/sbu064
PMCID: PMC4193725

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Comparison of the heritability of schizophrenia and endophenotypes in the COGS-1 family study.PMID 24903414Read ↗

Consortium on the Genetics of Schizophrenia (COGS) assessment of endophenotypes for schizophrenia: an introduction to this Special Issue of Schizophrenia Research.Semantic proximity Read ↗

Psychosis endophenotypes in schizophrenia and bipolar disorder.Semantic proximity Read ↗

Endophenotypes in the genetic analyses of mental disorders.Semantic proximity Read ↗

Analysis of 94 candidate genes and 12 endophenotypes for schizophrenia from the Consortium on the Genetics of Schizophrenia.Semantic proximity Read ↗

Genetic bases for endophenotypes in psychiatric disorders.Semantic proximity Read ↗

Factor structure and heritability of endophenotypes in schizophrenia: findings from the Consortium on the Genetics of Schizophrenia (COGS-1).Semantic proximity Read ↗

Initial heritability analyses of endophenotypic measures for schizophrenia: the consortium on the genetics of schizophrenia.Semantic proximity Read ↗

Deconstructing schizophrenia: an overview of the use of endophenotypes in order to understand a complex disorder.Semantic proximity Read ↗

Genome-wide Association of Endophenotypes for Schizophrenia From the Consortium on the Genetics of Schizophrenia (COGS) StudySemantic proximity Read ↗

Discovering schizophrenia endophenotypes in randomly ascertained pedigrees.Semantic proximity Read ↗

Endophenotype trait domains for advancing gene discovery in autism spectrum disorderSemantic proximity Read ↗

The Consortium on the Genetics of Endophenotypes in Schizophrenia: model recruitment, assessment, and endophenotyping methods for a multisite collaboration.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.