Article
Neurocognitive endophenotypes for bipolar disorder identified in multiplex multigenerational families.
Archives of general psychiatry - 1 Feb 2010
Glahn David C, Almasy Laura, Barguil Marcela, Hare Elizabeth, Peralta Juan Manuel, Kent Jack W, Dassori Albana, Contreras Javier, Pacheco Adriana, Lanzagorta Nuria, Nicolini Humberto, Raventós Henriette, Escamilla Michael A
Abstract excerpt
CONTEXT: Although genetic influences on bipolar disorder are well established, localization of genes that predispose to the illness has proven difficult. Given that genes predisposing to bipolar disorder may be transmitted without expression of the categorical clinical phenotype, a strategy for identifying risk genes is to identify and map quantitative intermediate phenotypes or endophenotypes. OBJECTIVE: To...
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