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A computational multiscale model of glioblastoma growth: regulation of cell migration and proliferation via microRNA-451, LKB1 and AMPK.

Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference - 1 Jan 2012

Schuetz Tina A, Becker Stefan, Mang Andreas, Toma Alina, Buzug Thorsten M

Abstract excerpt

A new computational multiscale model of glioblastoma growth is introduced. This model combines an agent-based model for representing processes on the cellular level with a molecular interaction network for each cell on the subcellular scale. The network is based on recently published work on the interaction of microRNA-451, LKB1 and AMPK in the regulation of glioblastoma cell migration and proliferation. We...

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AMP-Activated Protein Kinase Kinases
AMP-Activated Protein Kinases
Brain Neoplasms
Cell Movement

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 23367447
DOI: 10.1109/EMBC.2012.6347512

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