Article
MORC1 exhibits cross-species differential methylation in association with early life stress as well as genome-wide association with MDD.
Translational psychiatry - 26 Aug 2014
Nieratschker V, Massart R, Gilles M, Luoni A, Suderman M J, Krumm B, Meier S, Witt S H, Nöthen M M, Suomi S J, Peus V, Scharnholz B, Dukal H, Hohmeyer C, Wolf I A-C, Cirulli F, Gass P, Sütterlin M W, Filsinger B, Laucht M, Riva M A, Rietschel M, Deuschle M, Szyf M
Abstract excerpt
Early life stress (ELS) is associated with increased vulnerability for diseases in later life, including psychiatric disorders. Animal models and human studies suggest that this effect is mediated by epigenetic mechanisms. In humans, epigenetic studies to investigate the influence of ELS on psychiatric phenotypes are limited by the inaccessibility of living brain tissue. Due to the tissue-specific nature of...
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