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Individual longitudinal changes in DNA-methylome identify signatures of early-life adversity and correlate with later outcome

31 May 2024

Abstract excerpt

Adverse early-life experiences (ELA) affect a majority of the world's children. Whereas the enduring impact of ELA on cognitive and emotional health is established, there are no tools to predict vulnerability to ELA consequences in an individual child. Epigenetic markers including peripheral-cell DNA-methylation profiles may encode ELA and provide predictive outcome markers, yet the interindividual variance of...

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PMID: 38962694
DOI: 10.1016/j.ynstr.2024.100652

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