Article
Early life adversity alters normal sex-dependent developmental dynamics of DNA methylation.
Development and psychopathology - 1 Nov 2016
Massart Renaud, Nemoda Zsofia, Suderman Matthew J, Sutti Sheila, Ruggiero Angela M, Dettmer Amanda M, Suomi Stephen J, Szyf Moshe
Abstract excerpt
Studies in rodents, nonhuman primates, and humans suggest that epigenetic processes mediate between early life experiences and adult phenotype. However, the normal evolution of epigenetic programs during child development, the effect of sex, and the impact of early life adversity on these trajectories are not well understood. This study mapped the genome-wide DNA methylation changes in CD3+ T lymphocytes from...
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