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Article

Cell crowding induces interferon regulatory factor 9, which confers resistance to chemotherapeutic drugs

23 Aug 2014

Abstract excerpt

The mechanism of multicellular drug resistance, defined as the reduced efficacy of chemotherapeutic drugs in solid tumors is incompletely understood. Here we report that colon carcinoma cells cultured as 3D microtissues (spheroids) display dramatic increases in the expression of a subset of type I interferon-(IFN)-stimulated genes (ISGs). A similar gene signature was associated previously with resistance to...

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Share to Cytokine Signaling Pathways and Interactions
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 25156627
DOI: 10.1002/ijc.29161

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