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Suppression of interferon gene expression overcomes resistance to MEK inhibition in KRAS-mutant colorectal cancer

23 Oct 2018

Abstract excerpt

Despite showing clinical activity in BRAF-mutant melanoma, the MEK inhibitor (MEKi) trametinib has failed to show clinical benefit in KRAS-mutant colorectal cancer. To identify mechanisms of resistance to MEKi, we employed a pharmacogenomic analysis of MEKi-sensitive versus MEKi-resistant colorectal cancer cell lines. Strikingly, interferon- and inflammatory-related gene sets were enriched in cell lines...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 30353166
DOI: 10.1038/s41388-018-0554-z

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