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Article

Down-regulation of microRNA-196a in the sera and involved skin of localized scleroderma patients

1 Jul 2014

Abstract excerpt

BACKGROUND: Localized scleroderma (LSc) exhibits fibrosis of the skin and subcutaneous tissue. LSc shows an excessive deposition of type 1 collagen. OBJECTIVES: To elucidate the mechanism of type 1 collagen overexpression in LSc, we investigated the epigenetics, focusing on microRNA (miRNA). MATERIALS & METHODS: miRNA expression profile was determined by PCR array analysis. The expression of microRNA-196a...

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PMID: 25152444
DOI: 10.1684/ejd.2014.2384

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