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Detection of inherited mutations for hereditary cancer using target enrichment and next generation sequencing.

Familial cancer - 1 Mar 2015

Guan Yanfang, Hu Hong, Peng Yin, Gong Yuhua, Yi Yuting, Shao Libin, Liu Tengfei, Li Gairui, Wang Rongjiao, Dai Pingping, Bignon Yves-Jean, Xiao Zhe, Yang Ling, Mu Feng, Xiao Liang, Xie Zeming, Yan Wenhui, Xu Nan, Zhou Dongxian, Yi Xin

Abstract excerpt

Hereditary cancers occur because of inherited gene mutations. Genetic testing has been approved to provide information for risk assessment and rationale for appropriate intervention. Testing methods currently available for clinical use have some limitations, including sensitivity and testing throughput, etc. Next generation sequencing (NGS) has been rapidly evolving to increase testing sensitivity and throughput....

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Source

Identifiers

PMID: 25151137
DOI: 10.1007/s10689-014-9749-9

Genes

BRCA1
BRCA2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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