Article

Design and validation of a next generation sequencing assay for hereditary breast and ovarian cancer

2015-10-30

Abstract excerpt

Hereditary breast and ovarian cancer syndrome, caused by a germline deleterious variant in the BRCA1 or BRCA2 genes, is characterized by an increased risk for breast, ovarian, pancreatic and other cancers. Identification of those who have a BRCA1/2 mutation is important so that they can take advantage of genetic counseling, screening, and potentially life-saving prevention strategies. We describe the design and...

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Literature Corpus work: 1d6176ae-48a8-53f2-aa9e-7c189d026d97
DOI: 10.7287/peerj.preprints.1463v1

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