Article
G protein-coupled receptor accessory proteins and signaling: pharmacogenomic insights.
Methods in molecular biology (Clifton, N.J.) - 1 Jan 2014
Thompson Miles D, Cole David E C, Jose Pedro A, Chidiac Peter
Abstract excerpt
The identification and characterization of the genes encoding G protein-coupled receptors (GPCRs) and the proteins necessary for the processes of ligand binding, GPCR activation, inactivation, and receptor trafficking to the membrane are discussed in the context of human genetic disease. In addition to functional GPCR variants, the identification of genetic disruptions affecting proteins necessary to GPCR...
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