Genetics and Vitamin D Interactions in Osteoporosis: A Path to Precision Medicine.

Abstract excerpt

Osteoporosis is a systemic skeletal disease characterized by reduced bone mineral density (BMD) and increased fracture risk; it poses a significant global health challenge. The multifactorial pathogenesis of osteoporosis involves complex interactions between genetic factors and vitamin D metabolism, particularly involving key genes such as the vitamin D receptor (VDR), CYP27B1 and CYP24A1. Polymorphisms in these...

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